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KMID : 0606920110190010052
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Biomolecules & Therapeutics
2011 Volume.19 No. 1 p.52 ~ p.58
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Evaluation of Anti-Colitic Effect of Chung-Jang-Hwan (C-mix) in Mice
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Lee Ho-Yong
Ahn Young-Tae
Park Se-Hoon
Ahn Young-Min
Shim Jae-Jung
Lee Jung-Hee
Lee Jeong-Sang
Surh Young-Joon
Huh Chul-Sung
Kim Dong-Hyun
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Abstract
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The inhibitory effect of Chung-Jang-Hwan (C-mix) consisted of Geranium nepalense subsp. thunbergii, Saururus chinensis, and Rubus coreanus were investigated in dextran sulfate sodium (DSS)-induced colitic mice by microarray analysis. Treatment with Cmix improved colitic symptoms, including colon shortening and myeloperoxidase activity. Treatment with DSS alone upregulated the expression levels of infl ammation-related genes, including IL-1β, IL-6, CCL2, CCL4, CCL5, CCL7, CCL8, CCL24, CXCL1, CXCL2, CXCL5, CXCL9 and CXCL10, and other colitis-related genes such as COX-2, PAP, MMP family, S100a8, S100a9 and DEFA1 in mice. However, treatment with C-mix inhibited the expression levels of infl ammation-associated genes induced by DSS. The increased expression levels of COX-2 and IL-1β, representative infl ammatory genes, were confi rmed by a quantitative realtime polymerase chain reaction analysis. These results indicate that C-mix may ameliorate colitis by the inhibitory regulation of infl ammation-associated genes.
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KEYWORD
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Chung-Jang-Hwan, C-mix, Colitis, Inflammation, Microarray
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